Angelisa is a feminine given name of Greek origin, ultimately derived from the element angelos “messenger” with an appended diminutive-like suffix; it is pronounced in Greek as ahn-geh-LEE-kee (/aŋ.ɟe.li.ki/) and in English as an-jeh-LEE-suh (/ænˈdʒɪliːsə/). The name conveys a classical association with divine communication and purity, reflecting the archetype of the angelic intermediary. Analysis of U.S. Social Security data from 1959 through 2024 indicates that Angelisa has maintained a consistently low profile, with annual birth counts ranging between five and twenty-nine—peaking at twenty-nine in 2007 and returning to five by 2024—and national popularity ranks clustered around 800 to 960. This usage pattern suggests a niche adoption, favored by parents seeking traditional etymological roots and a distinctive phonetic structure rather than mainstream prevalence. In its structural composition, Angelisa bridges Greek etymology and Anglo-American naming conventions, offering both historical resonance and contemporary uniqueness.