Efrain—pronounced eh-FRAH-een—derives from the Spanish rendering of the Hebrew Ephraim, “fruitful” or, in the more optimistic footnotes, “doubly fruitful.” In Scripture, Ephraim became the progenitor of a tribe noted for its steady influence, a backstory that grants the name a quietly durable gravitas. One might say Efrain evokes the image of a Persian orchard: not ostentatious, yet year after year delivering pomegranates without fuss. American data reinforce this moderate reliability; for six decades the name has drifted between the 400s and 800s in national rankings, the on-call middleweight of the baby-name charts—visible, but never in danger of saturation. Predominantly chosen in Spanish-speaking families, it also carries an interfaith passport thanks to its Semitic roots, making it equally at ease in Sunday school, synagogue, or the boardroom. The three crisp syllables strike a balance between strength and melody, and parents who harbor ambitions beyond an apartment herb garden may appreciate the implicit promise in the meaning: plant Efrain, and expect a harvest.
| Efraín Escudero is a Mexican lightweight mixed martial artist who won season eight of The Ultimate Fighter and became the first Mexican fighter to compete in the UFC. |
| Efrain Esquivias Jr. - Efrain Esquivias is a Mexican American professional boxer who held the WBA Fedelatin super bantamweight title and trained under Freddie Roach at the Wild Card Boxing gym. |
| José Efraín Ríos Montt was a Guatemalan military officer who briefly ruled the country in the early 1980s, a period marked by some of the worst violence of the civil war and later accusations of genocide. |
| Efraín Huerta was a Mexican poet and journalist, a committed communist whose work spanned five decades and who invented the short, witty poetic form he called the poemínimo. |
| Efraín Recinos was a Guatemalan architect and artist best known for designing the jaguar-inspired Centro Cultural Miguel Angel Asturias, the country's national theater. |
| U.S.-born Efraín Álvarez is an attacking midfielder for Guadalajara and the Mexico national team. |
| Efraín Amador Piñero is a Cuban guitarist, composer and professor known for his research, teaching methods and compositions for the Cuban lute and tres. |
| Efraín Antonio Burgos is a former Salvadoran footballer who now manages Isidro Metapán. |
| Efraín González Morfín - Efraín González-Luna Morfín was a Mexican lawyer who ran for president in 1970 as the National Action Party candidate. |
| Efraín Velarde, nicknamed Chispa, is a retired Mexican footballer who made his name as a left-back. |
| Efraín Guzmán was a Colombian guerrilla leader and founding member of the FARC who died of natural causes in 2002. |
| Efraín Trelles was a Peruvian historian and writer who also became a beloved sports voice across print, television and radio. |
| Efraín Gutiérrez - César Gutiérrez is a Honduran defender who represented his country at the 1982 FIFA World Cup. |
| Efraín Flores is a Mexican professional football manager. |
| Efraín Sánchez was a Colombian goalkeeper who won three national league titles and played for his country at the 1962 World Cup in Chile. |