Genesee is a female name with American English pronunciation as juh-NEE-see (/dʒə'niːsiː/). The origin of the name is uncertain, but it is believed to have Native American roots. The name Genesee is associated with the Genesee River in New York and the Genesee County in Michigan. In terms of popularity, Genesee has had varying levels of usage over the years. In recent times, it has been given to only a handful of newborns each year in the United States. However, it is worth noting that name popularity can fluctuate, and some parents may find its uniqueness appealing.