Twayne is a male name with an origin rooted in English. It is pronounced as "twayn" in American English. One variation of this name is Twain. Twayne has been given to a small number of newborn boys in the United States of America, with occurrences recorded as early as 1974. While not a widely popular name, Twayne carries a unique and distinctive quality that can make it stand out among others. It evokes associations of strength, individuality, and charm. Consider choosing Twayne for your baby boy if you're looking for a name that is both uncommon and memorable.